ICSI is an approach in which an individual sperm is inserted directly into an egg; hence interactions between sperm and egg involved with normal fertilization are mostly ignored. ICSI method is micromanipulation method, which got its foundation somewhere in 1990’s and since then has gained much success in treating severe male infertility, along with sperm count testing, Delayed ejaculation, semen has no sperm.
Proof of ICSI:
- Couples facing total fertilization issues, in a previous IVF
- A low number of sperm concentrations, which provides a good amount of usable sperm which can be recovered from the injection of eggs.
- Dwindled sperm movement, including totally movable sperm
- Unusually high percentage of abnormal sperms, including round-headed sperm
- The absence of sperm in orgasm because of an obstruction caused due to congenital absence of vas deferens. TESE or testicular sperm extraction is used to get sperm for ICSI
- Ejaculatory dysfunction which is caused by retrograde ejaculation.
- Scientific factors: Anti-sperm antibodies in the female sear.
- Testicular cancer patients with semen samples frozen before treatment.
The ICSI treatment entails depriving cells of around the eggs and injecting a needle into the egg. A very less percentage of eggs, most often less healthy ones may be damaged and then corrupt by these procedures. Many times, the eggs themselves fail to fertilize in a normal way or arrest at an early stage of development.
ICSI pregnancy rates and live birth rates are very similar to those got from IVF. Studies have shown that blastocyst formation is reduced in comparison with IVF cycles, particularly in cases of poor sperm levels.
The casual selection of sperm has the potential for increased risks of abnormal embryos and birth defects including infertility.
ICSI is a very new concept. Children born as a result of ICSI are still very young and have yet to reach an age to reproduce. There are unknown long-term effects including those that could occur in generations to come.
What is Pseudo fertilization?
Pseudo fertilization or fertilization check is the process which has to be performed on laboratory, performed on the day after egg retrieval to know which eggs have fertilized in a normal way and can be used for embryo development and transfer.
Checking for fertilization of oocytes, the fertilized oocytes must be examined at least 16- 20 hours post insemination for presence.
Cost
The IVF treatment India cost is much better than other nations, because of this reason; only, people from all across the nations come to get their treatment done.
ICSI Benefits
ICSI sperm injection offers you and your partner a chance to have a baby, even with severe male infertility issues. ICSI helps you conceive if you are dealing with one or more of following conditions
- Low sperm level
- Physical blockage
- Poor sperm motility (movement) or morphology (shape)
- Having tried IVF without success
- The desire for pregnancy post-vasectomy
Could ICSI help us to conceive?
While ICSI the sperm doesn’t have to travel to egg or penetrate the outer layer of the egg. So, it can help couples where the man’s sperm fails to,
- Go to the egg or can get to the egg, but for some reason can’t fertilize it.
ICSI can be recommended in the following circumstances:
- A very low sperm count.
A high percentage of abnormally shaped sperms. The sperms which are not visible in fresh sample .but may be collected from testicles or from duct where the sperms are stored.
- Problems in erection and ejaculating
Sexual dysfunction is any kind of physical or psychological problem which prevents you or your partner from getting satisfaction from love making. Male sexual dysfunction is a common health problem which affects men of all age groups.
Success rates
The fertilization rate for ICSI may be high if you have been using conventional IVF methods, but pregnancy rate with ICSI is same as IVF pregnancy
| Age group | Level of success ( success rates) |
| 18 – 34 | 44% |
| 35- 37 | 39% |
| 38 – 39 | 30% |
| 40 – 42 | 21% |
| 43 – 44 | 11% |
Looking at the table above, one comes to know that the success rates decrease as we start getting older, so it is suggested that in case you wish to go in for the treatment, get it done as early as you can.
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